Who Should Not Use CBD? Uncovering Potential Risks and Interactions

Cannabidiol, commonly known as CBD, has risen in popularity as a supplement for a variety of health and wellness claims. It’s found in numerous products, from oils and tinctures to edibles and topical creams. While CBD is generally considered safe for many people and has potential health benefits, it’s not suitable for everyone. There are specific groups and circumstances where the use of CBD may pose risks.

Who Should Not Use CBD

Particular attention should be paid to how CBD interacts with other medications. Those on certain prescription drugs, like blood thinners or some anti-seizure medications, need to approach CBD with caution due to potential drug interactions. Additionally, there are underlying health conditions that complicate the use of CBD. For instance, liver issues or low blood pressure can be adversely affected by cannabidiol. The considerations surrounding pregnancy and breastfeeding also dictate abstaining from CBD, as the effects on fetal development and newborns are not well understood.

Drug and Medication Interactions

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When considering the use of CBD, it’s vital to understand that it can interact with various medications, potentially altering their effects. Specifically, CBD may influence the metabolization of drugs by the CYP450 liver enzymes. The CYP450 enzyme system is responsible for breaking down toxins and drugs in the body.

For individuals using blood thinners like warfarin, caution is advised as CBD might enhance the medication’s potency, increasing the risk of bleeding. Heart rhythm medications like amiodarone could also be affected, potentially leading to an irregular heartbeat.

People taking certain thyroid medications, such as levothyroxine, might experience changes in how their medication is metabolized, possibly requiring adjustments in dosing. Additionally, the effectiveness of seizure medications, including clobazam, lamotrigine, and valproate, can be diminished when taken alongside CBD.

  • Potential Effects on Drug Effectiveness:
    • Blood thinners (risk of bleeding)
    • Heart medications (irregular heartbeat)
    • Thyroid medications (altered metabolization)
    • Seizure medications (reduced effectiveness)

It’s essential to consult a healthcare professional before starting CBD, especially if other medications are part of one’s daily regimen. Health providers can offer personalized advice and adjustments if necessary. For further reading, one might be interested in perusing SingleCare’s resource on CBD-drug interactions.

Underlying Conditions: CBD Not Advised

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Certain medical conditions can make the use of CBD inadvisable due to potential risks and drug interactions. Individuals with these conditions should consult a healthcare professional before considering CBD use.

Liver Disease

CBD is metabolized in the liver, where it can affect the liver enzymes, particularly cytochrome P450. In individuals with liver disease, this could potentially worsen their condition or alter the effectiveness of other medications by affecting their metabolism. Those with liver-related issues should exercise caution and may be advised to avoid CBD products.

Kidney Disease

People with kidney disease may need to avoid CBD due to the body’s reduced ability to eliminate compounds, including CBD and its metabolites. Because kidneys are responsible for filtration, a compromised system might not handle the additional stress from the cannabinoids efficiently.


While CBD is utilized in the treatment of seizure disorders, the dosages and forms are highly regulated in medical contexts. If someone has epilepsy, they should not self-medicate with CBD without medical supervision, given that dosage and purity are crucial, and some over-the-counter CBD products may contain varying levels of THC, which could affect seizure control.

Heart Issues

Those with heart conditions need to approach CBD use with caution, as it can cause side effects like drowsiness and fatigue that might have implications for their overall heart health. CBD might also interact with heart medications, altering their intended effects.

Weakened Immune System

Individuals with weakened immune systems should be careful when using supplements, including CBD oil, as they can influence the immune response. With a lack of regulation in the purity and dosage of commercially available CBD products, the risks might outweigh the potential benefits. This group should seek medical advice before using any CBD product.

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Pregnancy & Breastfeeding

When it comes to CBD use during pregnancy and breastfeeding, caution is the watchword. The FDA strongly advises against the use of CBD, THC, and marijuana in any form during pregnancy or while breastfeeding. Studies and health authorities suggest that using CBD can pose potential risks to a developing baby or an infant.

During Pregnancy:

  • Risk of Low Birth Weight: CBD may increase the risk of a newborn being underweight.
  • Premature Birth: There’s a possibility of premature delivery associated with cannabis products.

While Breastfeeding:

  • Chemicals in Breast Milk: Chemicals ingested by the mother can be passed through breast milk, with potential effects on the baby.

Experts recommend avoiding CBD because not enough research has been done on its safety for infants. A baby’s brain is still developing, and cannabinoids may interfere with this process.

In Summary:

  • Pregnant women should steer clear of CBD to prevent potential harm to the baby’s development.
  • Breastfeeding mothers also should avoid CBD to protect their infants from ingesting any transferred substances that could be harmful.

For more detailed information, visit the FDA’s guidelines on Using CBD When Pregnant or Breastfeeding.

Frequently Asked Questions

In this section, readers will find detailed responses to common concerns regarding the use of CBD and the potential risks associated with its use, especially when it comes to interactions with medications and specific health conditions.

Are there specific medications that don’t mix well with CBD?

Yes, CBD can interact with various medications, such as blood thinners, that are metabolized by the same liver enzymes. It is crucial to consult with a healthcare provider before mixing CBD with prescription drugs.

Can CBD have negative effects on certain individuals?

Some individuals might experience side effects from CBD, such as dizziness, dry mouth, or changes in appetite. People with low blood pressure should be particularly cautious since CBD can lower blood pressure further.

What are the potential risks of incorporating CBD into my routine?

Introducing CBD into a daily routine may present risks, such as interactions with other supplements or medications and the quality of the CBD product. It is important to source CBD from reputable suppliers and to discuss its use with a healthcare provider.

Why might a healthcare provider advise against using CBD oil?

A healthcare provider might advise against using CBD oil if there’s a risk of interaction with prescribed medications or if an individual has a health condition that could be affected by CBD, such as liver issues or extremely low blood pressure.

Are some people more at risk when taking CBD products?

Yes, certain individuals, including pregnant or breastfeeding people, those with liver disease, and those taking medications with a narrow therapeutic index, may be more at risk when using CBD products due to potential adverse effects or interactions.

Is CBD universally safe, or are there exceptions?

While CBD is often touted for its safety profile, there are exceptions based on individual health conditions, potential medication interactions, and the possibility of impurities in CBD products. It’s best to exercise caution and seek professional medical advice before using CBD.